Platelet Function in Platelet Concentrates and in Whole Blood

An Overview on Platelet-derived Microparticles in Platelet Concentrates: blood collection, method preparation and storage

Preparations of platelet concentrates (PCs) that are stored under blood bank conditions and used for transfusion purposes, appear to be enriched in platelet derived-microparticles (PMPs) with high coagulant activity that may change platelet efficacy and safety issues. High shear stress could cause shedding of PMPs from the platelet plasma membrane, platelet aggregation, and activation of the co...

A Study on the Effects of Serotonin Reuptake Inhibitors on Platelet Function in Whole Blood and Platelet Concentrates

an overview on platelet-derived microparticles in platelet concentrates: blood collection, method preparation and storage

preparations of platelet concentrates (pcs) that are stored under blood bank conditions and used for transfusion purposes, appear to be enriched in platelet derived-microparticles (pmps) with high coagulant activity that may change platelet efficacy and safety issues. high shear stress could cause shedding of pmps from the platelet plasma membrane, platelet aggregation, and activation of the co...

Platelet Activation Test in Unprocessed Blood (Pac-t-UB) to Monitor Platelet Concentrates and Whole Blood of Thrombocytopenic Patients.

BACKGROUND Platelet concentrate transfusion is the standard treatment for hemato-oncology patients to compensate for thrombocytopenia. We have developed a novel platelet activation test in anticoagulated unprocessed blood (pac-t-UB) to determine platelet function in platelet concentrates and in blood of thrombocytopenic patients. METHODS We have measured platelet activity in a platelet concen...

Accumulation of di-2-ethylhexyl phthalate (DEHP) in whole blood, platelet concentrates, and platelet-poor plasma. 1. Effect of DEHP on platelet survival and function.

The widespread use of plastic bags in routine blood bank procedures has been attended by concern about the accumulation of substances from the plastic containers in the blood products and the biologic effects of these substances (1-11). Most poly(vinyl chloride) plastic bags contain di-2-ethylhexyl phthalate (DEHP) to make them pliable enough to prevent breakage (2, 5). This material has been s...